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By Edward S. Meek M D, Ch B, MRC Path (auth.)

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1965), who found that when tested in vivo against the MHV. 3 strain of mouse hepatitis virus, it increased the survival time of a test group when compared with that of the control group. ) grown in primary rabbit kidney cells. lgfml (or more) 24 hours before the virus inoculation, it prevented development of the cytopathic effect. lgfmI. , 1963). MURRAy-LYON et al. (1968) treated a case of malignant islet-cell tumour with streptozotocin and recorded symptomatic relief together with a decrease in the size of hepatic secondaries.

These investigators have reported that DNase is also effective in the treatment of herpetic keratitis, adenoviral keratitis, herpes zoster, and has a protective action against the spontaneous development of lymphatic leukaemia in mice if given in the preleukaemic period. They also report a positive response to DNase in human lymphoid leukaemia. LI et al. (1963) reported an antiviral substance to be present in aqueous extracts of calf thymus. The lyophilised preparation inhibited poliovirus and coxsackievirus in vitro.

Diethylstilboestrol and other oestrogens are valuable in the control of prostatic cancer. Progesterone has been used clinically for the treatment of endometrial carcinoma; VARGA and HENRIKSEN (1965) found that the clinical response was directly related to the extent of tumour differentiation. For many years corticosteroids have been used in the treatment of acute leukaemia in childhood and in malignant lymphomas. Prednisone and prednisolone are best used in combination with other drugs for the management of acute childhood leukaemia.

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