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Behavioral Pharmacology: The Current Status - download pdf or read online

By Bernard Weiss (auth.), Bernard Weiss, Victor G. Laties (eds.)

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In: Thirst, edited by M. J. Weyner. New York: Macmillan, 1964, p. 95-116. 26. FINDLEY, J. , W. W. ROBINSON AND L. PEREGRINO. Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means pf a self-infusion preference procedure. Psychopharmacologia 26: 93-114, 1972. 27. GOLDBERG, S. R. Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J. Pharmacol. Exp. Ther. 186: 18-30, 1973.

45 James H. Woods et al. , naloxone, can elicit a number of responses. The set of responses known as the morphine abstinence syndrome includes piloerection, emesis, diarrhea, rhinorrhea, miosis, and hyperreflexia (27). The magnitudes of some of the antagonist-elicited responses are related to the magnitude (dose) of the drug stimulus (31). Such elicited responses occur upon the initial administration of naloxone in morphine-dependent monkeys and usually are similar to the abstinence syndrome produced by an appropriate period of deprivation from morphine (34).

Thompson and Ostlund (71) made rats physicially dependent on morphine in one environment, detoxified them for 30 days, then readdicted half in a new environment and half in the original environment. Those readdicted in the original environment consumed morphine more readily than did those placed in a novel environment. Meisch and Thompson (43) studied ethanol self-administration on fixed ratio schedules by rats. On alternating days, rats had ethanol or tap water in a liquid reservoir concealed by the test panel.

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